Glycyrrhizic acid toxicity caused by consumption of licorice candy cigars.

Effects of hydroalcoholic extract of Glycyrrhiza glabra and glycyrrhizic acid on promastigote and amastigote of Leishmania major (MRHO/IR/75/ER)

Background: Cutaneous leishmaniasis by different species of Leishmania. Pentavalen antimonials as a first line drug for treatment of cutaneous leishmaniasis have several limitations and side effects. Natural products are more considered due to their less toxicity and cost, more efficient, safety and readily available antileishmania agents. Objective: The aim of this study was to explore the eff...

Central hypertensinogenic effects of glycyrrhizic acid and carbenoxolone.

The apparent mineralocorticoid excess syndrome of patients ingesting large amounts of licorice or its derivatives is thought to be caused by the antagonism by these compounds of the enzyme 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD). 11 beta-HSD inactivates cortisol and corticosterone, allowing the more abundantly produced glucocorticoids access to the mineralocorticoid receptor (MR) in ...

مقایسه اثر آنتی‌آنژیوژنیک عصاره تام آبی ریشه شیرین‌بیان و گلیسیریزیک اسید در پرده کوریوآلانتوئیک جوجه

Background: Angiogenesis, is an important process in physiological and pathological conditions as tumor growth and metastasis. Therefore, combinations that lead to inhibit angiogenesis may develop as an anti-cancer drug. In the present research, the anti-angiogenesis effect of Licorice root extract and Glycyrrhizic acid in Chorioallantoic membrane is investigated. Methods: In this experimental...

Effect of Ethanol Concentration in Ultrasound Assisted Extraction of Glycyrrhizic Acid from Licorice Root

Optimization of the Glycyrrhizic Acid Extraction from Licorice by Response Surface Methodology

This study aims to extract Glycyrrhizic Acid (GA) from Glycyrrhiza glabra L. (licorice) using a novel, high efficiency, and low-cost extraction method. Water was chosen as the proper solvent for the extraction process to eliminate the requirement of harmful and toxic solvents, prepare an environmentally friendly process, and reduce the costs. The effect of differe...